Methods and systems for cancelling self-interference in a full-duplex radio transceiver. The methods include transmitting a transmit signal from a transmit path of the transceiver and receiving a receive signal at a receive path of the transceiver. The receive signal has a self-interference signal component caused by self-interference between the transmit and receive paths. The methods further include generating a filtered signal by filtering an initial signal using an adaptive filter configured based on a target signal derived from the receive signal, wherein the initial signal is derived from the transmit signal; and subtracting a cancellation signal derived from the filtered signal from the receive signal. The target signal is derived from the receive signal by estimating the self-interference signal component in the receive signal, or the cancellation signal is derived from the filtered signal by estimating a part of the filtered signal equal to the self-interference signal component.