Disclosed are a driving method of a display panel and a display device. The driving method of the display panel includes: obtaining display data of a current display frame (S100); and inputting a data voltage to a data line according to the display data, so that the corresponding data voltages are charged into sub-pixels electrically connected to the data line (S200), where the data voltages inputted on the data line are divided into a plurality of voltage groups, each voltage group includes at least two adjacent data voltages, the polarities corresponding to the data voltages in a same voltage group are the same, the polarities corresponding to the data voltages of the two adjacent voltage groups inputted into a same data line are different, and the polarities of the corresponding voltage groups on the two adjacent data lines are different.