In various examples, one or more Machine Learning Models (MLMs) are used to identify content items in a video stream and present information associated with the content items to viewers of the video stream. Video streamed to a user(s) may be applied to an MLM(s) trained to detect an object(s) therein. The MLM may directly detect particular content items or detect object types, where a detection may be narrowed to a particular content item using a twin neural network, and/or an algorithm. Metadata of an identified content item may be used to display a graphical element selectable to acquire the content item in the game or otherwise. In some examples, object detection coordinates from an object detector used to identify the content item may be used to determine properties of an interactive element overlaid on the video and presented on or in association with a frame of the video.