Embodiments of the present invention provide transmission schemes and methods that can assign multiple resource units (RUs) to a single wireless station using Aggregate Media Access Control Protocol Data Unit (A-MPDUs) in a flexible transmission scheme for the multi-RUs transmission. Embodiments of the present invention can send and receive data sing multiple resource units allocated to a single wireless STA. A 20 MHz segment and a 40 MHz segment on either side of a punctured portion of an 80 MHz segment can be treated as separate resource units (RUs), and the RUs can be assigned to the same wireless user/device. Each punctured 80 MHz segment can be interleaved separately. Different processes for encoding data and transmission schemes for transmitting the data are described herein according to embodiments of the present invention. Different transmission schemes can be used based on the size and number of the RUs allocated to an STA.