The present disclosure provides a method for predicting co-channel interference (CCI) of a satellite-to-ground downlink under a low-orbit satellite constellation. The method includes: obtaining CCI values in a first time period and CCI values in a second time period; constructing a CCI model based on the CCI values in the first time period and a dropout wavelet neural network (WNN); updating parameters of the CCI model; inputting the CCI values in the second time period into an updated CCI model to obtain accuracy; determining whether the accuracy is greater than an accuracy threshold; and if the accuracy is greater than the accuracy threshold, reconstructing the CCI model; or if the accuracy is less than or equal to the accuracy threshold, outputting the updated CCI model; and predicting CCI values of each link at a next moment based on the updated CCI model.