RF communication systems with interference cancellation for coexistence are provided herein. In certain embodiments, a method of interference cancellation includes filtering a radio frequency (RF) transmit signal to generate a first RF feedback signal using a first filter of a front end system, filtering the RF transmit signal to generate a second RF feedback signal using a second filter of the front end system, processing the first RF feedback signal to generate a first digital interference cancellation signal using a first feedback receiver, processing the second RF feedback signal to generate a second digital interference cancellation signal using a second feedback receiver, and compensating an RF receive signal for interference based on the first digital interference cancellation signal and the second digital interference cancellation signal using a receiver.