The disclosure relates to a method for streamlining baggage screening across modes of transportation. The method includes scanning a baggage item at an airport and uploading scanned baggage imagery of the contents and license plate identification to a secure cloud storage system. A screening manifest is generated which lists an additional mode of transportation requiring different screening rules. The contents of the stored baggage imagery are reanalyzed according to these different rules and regulations, to determine compliance, and creates a baggage authorization record. Based on the compliance result, represented by an indicium affixed to the baggage, a trusted custody handler can directly deliver the baggage to the next mode of transportation without additional screening, or direct it for further security screening if non-compliant. This system improves efficiency and security in multi-modal transportation networks.