The present disclosure provides a signal selection circuit and a signal selection method of a display panel, and a display device. The display panel has N regions and includes pixel driving circuits and M gate driving circuits for providing M gate driving signals to the pixel driving circuits; each gate driving circuit includes N gate driving sub-circuits, each of which is configured to provide one gate driving signal to the pixel driving circuits in one region; M≥2, N≥2, and M and N are integers; the signal selection circuit includes: M frame start signal lines, each of which is configured to provide a frame start signal for one gate driving circuit; and a selection sub-circuit configured to output frame start signals written by the frame start signal lines to the gate driving sub-circuits corresponding to the regions of the display panel according to a preset sequence.