Invention Application
- Patent Title: Analogs of benzoquinone-containing ansamycins and methods of use thereof
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Application No.: US11108165Application Date: 2005-04-14
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Publication No.: US20060014731A1Publication Date: 2006-01-19
- Inventor: Julian Adams , Yun Gao , Asimina Georges Evangelinos , Louis Grenier , Roger Pak , James Porter , James Wright
- Applicant: Julian Adams , Yun Gao , Asimina Georges Evangelinos , Louis Grenier , Roger Pak , James Porter , James Wright
- Main IPC: C07D225/04
- IPC: C07D225/04 ; C07D491/02 ; A61K31/33
Abstract:
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
Public/Granted literature
- US07375217B2 Analogs of benzoquinone-containing ansamycins and methods of use thereof Public/Granted day:2008-05-20
Information query
