Invention Application
US20070218005A1 NUCLEI DENSITY AND NUCLEI AREA METHODS FOR DETERMINING THE EFFECTS OF A BOTULINUM TOXIN ON MUSCLES
审中-公开
核酸密度和核酸区域确定火鸡毒素对马铃薯的影响的方法
- Patent Title: NUCLEI DENSITY AND NUCLEI AREA METHODS FOR DETERMINING THE EFFECTS OF A BOTULINUM TOXIN ON MUSCLES
- Patent Title (中): 核酸密度和核酸区域确定火鸡毒素对马铃薯的影响的方法
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Application No.: US11749427Application Date: 2007-05-16
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Publication No.: US20070218005A1Publication Date: 2007-09-20
- Inventor: James Holland , Edward Chow
- Applicant: James Holland , Edward Chow
- Applicant Address: US CA Irvine
- Assignee: ALLERGAN, INC.
- Current Assignee: ALLERGAN, INC.
- Current Assignee Address: US CA Irvine
- Main IPC: A61K49/00
- IPC: A61K49/00
Abstract:
Methods for determining the effect of a Clostridial neurotoxin on muscle are disclosed. In particular, methods for determining a potency and/or diffusion of a neurotoxin based on a nuclear index and/or an amount of muscle atrophy are disclosed. The methods may be used to distinguish two different Clostridial neurotoxins. In certain embodiments, the neurotoxins are obtained from Clostridium botulinum.
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