A method of and system for calibrating an imaging device is described herein. An iterative method that attempts to find the best calibration parameters conditional upon an error metric is used. Regression is used to estimate values in a color space where the calibration is performed based upon a training data set. More calculation steps are required than would be for a regression in raw RGB space, but the convergence is faster in the color space where the calibration is performed, and the advantages using boundary conditions in the color space is able to provide improved calibration.