A light emitting diode lens structure includes a lens having an upper section and a lower section. The lower section is provided with a light emitting diode accommodation part. The upper section is coated with a specular reflection layer to form a reflecting surface facing the light emitting diode accommodation part. An illumination apparatus with the light emitting diode lens structure includes a lampshade, a locking module, an electrode module, and a light emitting diode. The lampshade has a reflecting light surface and an aperture. The locking module is coupled on the lampshade and has a through hole corresponding to the aperture. The electrode module is coupled on the locking module and corresponds to the through hole. This design provides a significant reduction in glare to reduce eyestrain.