A multi-mode foldable mouse includes a main body, a cover, a sensing device and a controller. A first touch panel is disposed on the main body. A second touch panel is disposed on the cover. The sensing device is used for sensing a position of the main body relative to the cover. The controller is used for controlling the mouse to be operated in either a multi-touch mode or a keyboard mode according to the position of the main body relative to the cover. When the mouse in operated in the multi-touch mode, the first touch panel is enabled, and a multi-finger inputting operation on the first touch panel is converted into an image control instruction. When the mouse in operated in a keyboard mode, a virtual standard keyboard is shown on the first touch panel in cooperation with the second touch panel for providing a function of inputting characters.