Invention Application
US20120129858A1 COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES
审中-公开
化合物，组合物和包含吡咯烷酮磺酰胺衍生物的方法
- Patent Title: COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES
- Patent Title (中): 化合物，组合物和包含吡咯烷酮磺酰胺衍生物的方法
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Application No.: US13265131Application Date: 2010-04-19
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Publication No.: US20120129858A1Publication Date: 2012-05-24
- Inventor: Stephen David Penrose , Kevin James Doyle
- Applicant: Stephen David Penrose , Kevin James Doyle
- Assignee: INSTITUTE FOR ONEWORLD HEALTH
- Current Assignee: INSTITUTE FOR ONEWORLD HEALTH
- International Application: PCT/US10/31608 WO 20100419
- Main IPC: A61K31/50
- IPC: A61K31/50 ; C07D237/14 ; C07D417/10 ; A61K31/501 ; A61P1/12 ; A61P13/12 ; A61P29/00 ; A61P1/00 ; A61P31/00 ; A61P9/06 ; A61P15/08 ; A61P9/00 ; C07D413/14 ; A61K31/5377 ; C12N5/02 ; C07D237/20
Abstract:
The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-3 or encompassed by formula I-III) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
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