Invention Application
- Patent Title: MICRONEEDLE DEVICE HAVING A PEPTIDE THERAPEUTIC AGENT AND AN AMINO ACID, METHODS OF MAKING AND USING THE SAME
- Patent Title (中): 具有肽治疗剂和氨基酸的微型装置，制备和使用它们的方法
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Application No.: US14361802Application Date: 2012-11-30
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Publication No.: US20140330198A1Publication Date: 2014-11-06
- Inventor: Ying Zhang , Percy T. Fenn , Peter R. Johnson
- Applicant: 3M INNOVATIVE PROPERTIES COMPANY
- International Application: PCT/US2012/067278 WO 20121130
- Main IPC: A61K47/22
- IPC: A61K47/22 ; A61K47/18 ; A61M37/00 ; A61K38/28 ; A61K38/47 ; A61K38/29 ; A61K38/22
Abstract:
A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.
Public/Granted literature
Information query
