The present invention relates to flame retardant thermoplastic polyurethane (TPU) compositions, and more particularly to flame retardant thermoplastic polyurethane compositions comprising non-halogen flame retardants. The TPU compositions of this invention are useful for applications where high flame performance, optionally low smoke properties, as well as high tensile strength are desirable, such as wire and cable applications, film applications, molding applications, and the like. This invention also relates to processes to produce the described non-halogen flame retardant TPU compositions and processes to produce wire and cable jacketing from such compositions.