A method for predicting subject trustworthiness includes using at least one classifier to predict truthfulness of subject responses to prompts during a local or remote interview, based on subject responses and response times, as well as interviewer impressions and response times, and, in embodiments, also biometric measurements of the interviewer. Data from the subject interview is normalized and analyzed relative to an experience database previously created using data obtained from test subjects. Classifier prediction algorithms incorporate assumptions that subject response times are indicators of truthfulness, that subjects will tend to be consistently truthful or deceitful, and that conscious and subconscious impressions of the interviewer are predictive of subject trustworthiness. Data regarding interviewer impressions can be derived from interviewer response times, interviewer questionnaire answers, and/or interviewer biometric data. Appropriate actions based on trustworthiness predictions can include denial of security clearance or further investigation relevant to the subject.