Systems and methods are disclosed herein that may implement an information handling system including a gateway and a peripheral device monitor. The gateway may interface peripheral devices and control access of host resources of the information handling system by any of the peripheral devices. The peripheral device monitor may detect connection of an unverified peripheral device to the gateway, perform a trust verification process with the unverified peripheral device, control the gateway to enable access of the host resources by the unverified peripheral device when the unverified peripheral device becomes verified, and control the gateway to prevent access to the host resources by the unverified peripheral device when the unverified peripheral device fails the trust verification process. The trust verification process may include validating a device certificate and verifying a digest of boot code of the peripheral device. The peripheral device monitor may perform a verification failure procedure when the unverified peripheral device fails the trust verification process.