Invention Application
- Patent Title: METHODS AND COMPOUNDS FOR TARGETING SORTILIN RECEPTORS AND INHIBITING VASCULOGENIC MIMICRY
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Application No.: US17270787Application Date: 2019-08-26
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Publication No.: US20220000971A1Publication Date: 2022-01-06
- Inventor: Richard BÉLIVEAU , Borhane ANNABI , Michel DEMEULE , Alain LAROCQUE , Jean-Christophe CURRIE , Alain ZGHEIB
- Applicant: TRANSFERT PLUS, S.E.C.
- Applicant Address: CA Montreal
- Assignee: TRANSFERT PLUS, S.E.C.
- Current Assignee: TRANSFERT PLUS, S.E.C.
- Current Assignee Address: CA Montreal
- International Application: PCT/CA2019/051170 WO 20190826
- Main IPC: A61K38/16
- IPC: A61K38/16 ; A61K47/64 ; A61P35/00
Abstract:
The present disclosure relates to peptide compounds and conjugate compounds, processes, methods and uses thereof for treatment of cancer or aggressive cancer. For example, the compounds can comprise compounds of formula X1X2X3X4X5GVX6AKAGVX7NX8FKSESY (I) (SEQ ID NO: 1) (X9)nGVX10AKAGVX11NX12FKSESY (II) (SEQ ID NO: 2) YKX13LRRX14APRWDX15PLRDPALRX16X17L (III) (SEQ ID NO: 3) YKX18LRR(X19)nPLRDPALRX20X21L (IV) (SEQ ID NO: 4) IKLSGGVQAKAGVINMDKSESM (V) (SEQ ID NO: 5) IKLSGGVQAKAGVINMFKSESY (VI) (SEQ ID NO: 6) IKLSGGVQAKAGVINMFKSESYK (VII) (SEQ ID NO: 7) GVQAKAGVINMFKSESY (VIII) (SEQ ID NO: 8) GVRAKAGVRNMFKSESY (IX) (SEQ ID NO: 9) GVRAKAGVRN(Nle)FKSESY (X) (SEQ ID NO: 10) YKSLRRKAPRWDAPLRDPALRQLL (XI) (SEQ ID NO: 11) YKSLRRKAPRWDAYLRDPALRQLL (XII) (SEQ ID NO: 12) YKSLRRKAPRWDAYLRDPALRPLL (XIII) (SEQ ID NO: 13) wherein X1 to X21 and n can have various different values and wherein at least one protecting group and/or at least one labelling agent is optionally connected to said peptide compound at an N- and/or C-terminal end, for use in inhibiting vasculogenic mimicry and/or for treating a cancer.
Information query
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