Embodiments herein relate to devices and related systems and methods for motion sickness prevention and mitigation. In an embodiment, a method of preventing or mitigating motion sickness in a subject is included, the method tracking motion of the subject using a first motion sensor; estimating a vestibular system input based on tracked motion of the subject; tracking head position of the subject using the first motion sensor; estimating a visual system input based on tracked head position of the subject; estimating consistency between the vestibular system input and the visual system input; and initiating a responsive measure if the estimated consistency crosses a threshold value. Other embodiments are also included herein.