Embodiments of this invention relate generally to a miniature multi-spectral system to detection pathogen, biomarkers, or any compound from a sample. In one example, a miniature multi-spectral system comprises a first miniature spectrometer to generate a first spectral output based on a sample, a second miniature spectrometer to generate a second spectral output based on the sample, and a processor coupled to the first and the second miniature spectrometers. The processor is configured to execute instructions to perform data fusion of the first and second spectral outputs to generate fused data, and to apply artificial intelligence (AI) of an AI module to the fused data to identify a pathogen, biomarker, or any compound from the sample.