A hot-spinning formation method for large-diameter titanium alloy cylindrical parts. A workblank is placed in a resistance furnace to heated to 600-650° C., is maintained at this temperature for 0.5-1 h and is then taken out of the resistance furnace; after the workblank is heated, the inner diameter of the workblank becomes larger; the heated workblank is installed on a mandrel, and spinning is started when a maximum clearance between the workblank and the mandrel is less than 0.5 mm; the mandrel and the spinning rollers do not need to be preheated, and a multi-pass spinning process is adopted, such that the workblank can deform more uniformly. A vertical spinning lathe is used for spinning, the mandrel is easy to change, and the workblank is easy to assemble and disassemble.