Invention Publication
- Patent Title: HIGH CONCENTRATION ANTIBODY-CONTAINING LIQUID FORMULATION
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Application No.: US18162368Application Date: 2023-01-31
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Publication No.: US20230167183A1Publication Date: 2023-06-01
- Inventor: Toshiyuki MORICHIKA , Daisuke KAMEOKA , Yoshimi IMAEDA , Terutoshi MAEDA , Oliver Boris STAUCH
- Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA , HOFFMANN-LA ROCHE INC.
- Applicant Address: JP NJ Tokyo
- Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA,HOFFMANN-LA ROCHE INC.
- Current Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA,HOFFMANN-LA ROCHE INC.
- Current Assignee Address: JP NJ Tokyo
- Priority: JP 63102007 2007.12.27
- The original application number of the division: US17752978 2022.05.25
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/395 ; A61K47/18 ; A61K47/26 ; C07K1/14 ; A61K47/20

Abstract:
The problem to be solved is to provide a humanized anti-IL-6 receptor antibody MRA-containing formulation which is suitable for subcutaneous administration, wherein dimerization or deamidation is prevented during long-term storage. The present application is directed to a stable antibody-containing liquid formulation characterized by containing arginine and histidine buffer. A method of inhibiting deamidation or dimerization of such an antibody in a concentrated liquid formulation includes histidine buffer in the liquid formulation.
Public/Granted literature
- US11767363B2 High concentration antibody-containing liquid formulation Public/Granted day:2023-09-26
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