An ESD protection device includes a semiconductor body having an upper surface, a plurality of p-type wells that each extend from the upper surface into the semiconductor body, a plurality of n-type wells that each extend from the upper surface into the semiconductor body, first isolation regions comprising an electrical insulator that laterally surrounds the p-type wells and extends from the upper surface into the semiconductor body at least as deep as the p-type wells, and second isolation regions comprising an electrical insulator that laterally surrounds the n-type wells and extends from the upper surface into the semiconductor body at least as deep as the n-type wells, wherein the p-type wells and the n-type wells alternate with one another a first direction, and wherein an isolating area of the first isolation regions is greater than an isolating area of the second isolation regions.