Disclosed are a method and an apparatus for uplink transmission and reception in a wireless communication system. A method for transmitting an uplink channel according to an embodiment of the present disclosure may comprise the steps of: receiving downlink control information (DCI) from a base station; and transmitting the uplink channel to the base station on the basis of the DCI. N (N is a natural number) transmit power control (TCI) command values may be indicated by the DCI, and transmission power of the uplink channel may be determined on the basis of one of the N TPC command values.