Invention Publication
- Patent Title: METHOD FOR DIAGNOSING AND TREATING BLOOD CANCER
-
Application No.: US17919735Application Date: 2021-06-11
-
Publication No.: US20230193350A1Publication Date: 2023-06-22
- Inventor: Yuki Kurahashi , Magoichi Sako , Hiroo Wakita , Shinya Kimura , Tatsuro Watanabe , Yuta Yamamoto
- Applicant: Ohara Pharmaceutical Co., Ltd. , Saga University
- Applicant Address: JP Koka-shi Shiga
- Assignee: Ohara Pharmaceutical Co., Ltd.,Saga University
- Current Assignee: Ohara Pharmaceutical Co., Ltd.,Saga University
- Current Assignee Address: JP Koka-shi Shiga
- Priority: JP 20102904 2020.06.15
- International Application: PCT/JP2021/022226 2021.06.11
- Date entered country: 2022-10-18
- Main IPC: C12Q1/42
- IPC: C12Q1/42 ; A61K31/53 ; A61K31/497 ; A61P35/00

Abstract:
The present invention provides: a method for identifying a blood cancer patient who may benefit from a monotherapy using a drug comprising a DNA methyl transferase inhibitor and a combination therapy using the aforesaid drug together with another epigenetic controller; a pharmaceutical composition to be used in treating a patient who has been identified or selected by the method; and a kit for identifying such a patient. More particularly, the aforesaid method comprises a step for measuring the expression amount of DUSP5 in a sample obtained from a blood cancer patient. When the expression amount measured in this step is lower than a reference expression amount of DUSP5, then the patient is identified or selected as a blood cancer patient who may benefit from a treatment using the drug comprising a DNA methyl transferase inhibitor.
Information query