A spectrally multiplexed quantum repeater (SMuQR) based on spatially arrayed nodes of frequency-multiplexed multi-qubit registers uses the natural inhomogeneous distribution of optical transition frequencies in solid state defect centers. This distribution enables spectrally selective, individual addressing of large numbers of defect centers within an optical diffraction limited spot along a long cavity or waveguide. The spectral selection relies on frequency shifting an incident optical field at a rate as fast as once per defect center lifetime. The defect centers are resonant at visible frequencies and emit visible single photons which are down-converted to a wavelength compatible with long-distance transmission via conventional optical fiber. The down-converted photons are all at the same telecommunications wavelength, with the different spectral bins mapped to different temporal bins to preserve the multiplexing in the time domain, for distribution to other nodes in the quantum network.