An information processing apparatus includes at least one processor which functions to acquire information indicating capability of a printing apparatus and control to perform rotation processing for a print target for each layout region on a print medium. The at least one processor functions to control to transmit the print target to the printing apparatus without rotating an image of the print target to be laid out in a first layout region if the capability of the printing apparatus satisfies a predetermined condition based on the acquired information, and transmit the print target to the printing apparatus by rotating the image of the print target to be laid out in the first layout region if the capability of the printing apparatus does not satisfy the predetermined condition based on the acquired information.