The present disclosure advantageously refers to systems and methods for predicting an oil mixture's blend compatibility without mixing the components and/or without performing direct blend testing. The techniques described use a correlation between near infrared spectroscopic information, asphaltene solubility parameter Ra, and maltene solubility parameter Po to accurately predict blend compatibility using the equation P=Po(blend)/Ra(blend). A P≥1 indicates the blend is compatible. These techniques are useful in, for example, refineries to predict and therefore reduce or eliminate fouling due to asphaltene deposits.