Invention Publication
- Patent Title: MACROCYCLIC AZOLOPYRIDINE DERIVATIVES AS EED AND PRC2 MODULATORS
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Application No.: US18085134Application Date: 2022-12-20
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Publication No.: US20240139163A1Publication Date: 2024-05-02
- Inventor: Ivan Viktorovich Efremov , Steven Kazmirski , Qingyi Li , Lorin A. Thompson, III , Owen Brendan Wallace , Shawn Donald Johnstone , Feng Zhou , Peter Rahl
- Applicant: Fulcrum Therapeutics, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Fulcrum Therapeutics, Inc.
- Current Assignee: Fulcrum Therapeutics, Inc.
- Current Assignee Address: US MA Cambridge
- Main IPC: A61K31/4355
- IPC: A61K31/4355 ; A61K31/437 ; A61K45/06 ; C07D498/16 ; C07D498/22
Abstract:
The invention relates to modulators of Embryonic Ectoderm Development (EED) and/or Polycomb Repressive Complex 2 (PRC2) useful in the treatment of disorders and diseases associated with EEC and PRC2, being macrocyclic azolopyridine derivatives and compositions thereof of Formula I:
or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, enantiomer, isomer, or tautomer thereof, wherein X1, X2, X3, A1, A2, Y, R1, R2, R3, and R4 are as described herein.
or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, enantiomer, isomer, or tautomer thereof, wherein X1, X2, X3, A1, A2, Y, R1, R2, R3, and R4 are as described herein.
Public/Granted literature
- US12109198B2 Macrocyclic azolopyridine derivatives as EED and PRC2 modulators Public/Granted day:2024-10-08
Information query
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