An electrolyzer plant comprising a plurality of electrolyzer modules includes a system having a processing unit that determines, for each of the plurality of electrolyzer modules, an electrolyzer module set point at which the electrolyzer module is to be operated, and controls operation of each of the plurality of electrolyzer modules at the respective electrolyzer module set point. The determining comprises inputting data representative of operation characteristics of each of the plurality of electrolyzer modules into the processing unit and the processing unit performing an optimization procedure that outputs the electrolyzer module set points, the optimization procedure comprising an optimization for one or more of overall electrolyzer plant efficiency, overall plant lifetime, lifetime of each of the electrolyzer modules, operational safety, and maintenance patterns.