Examples include an image sensor comprising a pixel array having at least one column of addressable pixel sensors, and a column amplifier coupled to the at least one column of addressable pixel sensors, the column amplifier comprising a transistor bank including a plurality of transistors, and mode select circuitry coupled to the transistor bank and configured to establish one or more connections among the plurality of transistors to configure the column amplifier to operate in one of a differential mode of operation and a single-ended mode of operation.