Invention Grant
- Patent Title: Succinic acid compounds
- Patent Title (中): 化合物
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Application No.: US860023Application Date: 1992-03-30
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Publication No.: US5202335APublication Date: 1993-04-13
- Inventor: Fumiyasu Sato , Atsushi Tsubaki , Hiroshi Hokari , Nobuyuki Tanaka , Masaru Saito , Kenji Akahane , Michihiro Kobayashi
- Applicant: Fumiyasu Sato , Atsushi Tsubaki , Hiroshi Hokari , Nobuyuki Tanaka , Masaru Saito , Kenji Akahane , Michihiro Kobayashi
- Applicant Address: JPX Nagano
- Assignee: Kissei Pharmaceutical Co., Ltd.
- Current Assignee: Kissei Pharmaceutical Co., Ltd.
- Current Assignee Address: JPX Nagano
- Priority: JPX3-142275 19910330; JPX3-188416 19910425; JPX3-361519 19911227
- Main IPC: C07D209/08
- IPC: C07D209/08 ; C07D209/44 ; C07D217/06 ; C07D409/06
Abstract:
Succinic acid compounds of the formula: ##STR1## wherein A represents a heterocyclic group, a 3 to 8-membered cycloalkyl group or a phenyl group which may have one or more substituents selected from the group of a halogen atom, a lower alkyl group having 1 to 6 carbon atoms and a lower alkoxy group having 1 to 6 carbon atoms; B represents a bicyclic amino group which may have 1 or 2 unsaturated bonds, with the proviso that B bonds to the carbon atom of the carbonyl group at the nitrogen atom; R represents a hydrogen atom or combines each other to form a chemical bond; R.sup.1 represents a hydrogen atom, a lower alkyl group having 1 to 6 carbon atoms or an aralkyl group having 7 to 10 carbon atoms; when there is an asymmetric carbon atom, enantiomers thereof and racemic mixtures thereof; when there are geometrical isomers, each geometrical isomer, E-isomers thereof, Z-isomers thereof, cis-isomers thereof and trans-isomers thereof; and pharmaceutically acceptable salts thereof, enhance insulin secretion and possess a hypoglycemic activity, and are thus useful for the treatment of diabetes.
Public/Granted literature
- US6111058A Biodegradable polyesteramide and a process of preparing Public/Granted day:2000-08-29
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