Invention Grant
- Patent Title: Peptides specific for the first Crk-SH3 domain
- Patent Title (中): 特定于第一个Crk-SH3结构域的肽
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Application No.: US367070Application Date: 1994-12-30
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Publication No.: US5888763APublication Date: 1999-03-30
- Inventor: Hidesaburo Hanafusa , Beatrice S. Knudsen , Stephan M. Feller , John Kuriyan , Xiaodong Wu , Jie Zheng , David Cowburn
- Applicant: Hidesaburo Hanafusa , Beatrice S. Knudsen , Stephan M. Feller , John Kuriyan , Xiaodong Wu , Jie Zheng , David Cowburn
- Applicant Address: NY New York
- Assignee: The Rockefeller University
- Current Assignee: The Rockefeller University
- Current Assignee Address: NY New York
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K14/47 ; C12P21/06 ; C07H21/00 ; C12N1/20
Abstract:
The present invention relates to regulation and control of cellular processes by SH3-domain binding proteins and peptides. In particular, the invention provides a consensus sequence of a peptide that shows high specificity and affinity for the first SH3 domain of cellular Crk. In specific examples, a number of peptides that contain the consensus are shown to bind c-Crk specifically. The molecular basis for this specificity is examined by crystallography.
Public/Granted literature
- US6139693A Method for obtaining hexamethylene diamine from mixtures containing hexamethylene diamine Public/Granted day:2000-10-31
Information query
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