A fluid-handling system capable, in various embodiments, of storing, mixing, and dispensing fluids, and also regulating the flow of fluids. The system includes a cartridge having a non-expandable housing, and a bladder within the housing. In some variations, a drive-liquid is introduced into a region between the housing and the bladder, which causes fluid contained within the bladder to dispense. In some other variations, the drive-liquid is introduced into the bladder, which causes the bladder to expand and expel fluid that is contained with the housing.