A vehicle-based door opening system for opening a door at a building includes a vehicle-based transmitting unit, a control and an actuating device. The transmitting unit is positioned at the vehicle and operable to transmit a first signal, and the actuating device is positioned at the building and receives the first signal from the vehicle-based transmitting unit. The control is operable to control at least one vehicle-based accessory, such as a door lock mechanism, in response to the first signal. The actuating device receives a domestic hand held garage door opener transmitting unit associated with a door opening device at or near the door and actuates the domestic hand held garage door opener transmitting unit in response to the first signal. The domestic hand held garage door opener transmitting unit transmits a second signal to actuate the door opening device to open or close the door.