Invention Grant
US07172862B2 FBL2-specific agents as modulators of Flaviviridae RNA replication
有权
FBL2特异性试剂作为黄病毒科RNA复制的调节剂
- Patent Title: FBL2-specific agents as modulators of Flaviviridae RNA replication
- Patent Title (中): FBL2特异性试剂作为黄病毒科RNA复制的调节剂
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Application No.: US11122373Application Date: 2005-05-04
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Publication No.: US07172862B2Publication Date: 2007-02-06
- Inventor: Michael J. Gale, Jr. , Michael S. Brown , Joseph L. Goldstein , Chunfu Wang , Jin Ye
- Applicant: Michael J. Gale, Jr. , Michael S. Brown , Joseph L. Goldstein , Chunfu Wang , Jin Ye
- Applicant Address: US TX Austin
- Assignee: Board of Regents, The University of Texas System
- Current Assignee: Board of Regents, The University of Texas System
- Current Assignee Address: US TX Austin
- Agent Richard Aron Osman
- Main IPC: C12Q1/70
- IPC: C12Q1/70 ; C12P21/06 ; G01N33/53
Abstract:
Agents that modulate an interaction of an FBL2 protein with an NS5A or NS5B Flaviviridae protein in a mixture are identified by contacting the mixture with a candidate agent under conditions wherein but for the presence of the agent, the FBL2 protein and the Flaviviridae protein engage in a reference interaction; and detecting an agent-biased interaction. Flaviviridae replication is inhibited by contacting a Flaviviridae-infected cell with an FBL2-specific reagent; and detecting a resultant Flaviviridae replication inhibition.
Public/Granted literature
- US20060252119A1 FBL2-specific agents as modulators of Flaviviridae RNA replication Public/Granted day:2006-11-09
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