Invention Grant
US07229605B2 Nuclei density and nuclei area methods for determining effects of a botulinum toxin on muscles
失效
用于确定肉毒杆菌毒素对肌肉的影响的核密度和核区域方法
- Patent Title: Nuclei density and nuclei area methods for determining effects of a botulinum toxin on muscles
- Patent Title (中): 用于确定肉毒杆菌毒素对肌肉的影响的核密度和核区域方法
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Application No.: US10918845Application Date: 2004-08-13
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Publication No.: US07229605B2Publication Date: 2007-06-12
- Inventor: James M. Holland , Edward Chow
- Applicant: James M. Holland , Edward Chow
- Applicant Address: US CA Irvine
- Assignee: Allergan, Inc.
- Current Assignee: Allergan, Inc.
- Current Assignee Address: US CA Irvine
- Agent Claude L. Nassif; Stephen Donovan; Martin A. Voet
- Main IPC: A61K49/00
- IPC: A61K49/00
Abstract:
Methods for determining the effect of a Clostridial neurotoxin on muscle are disclosed. In particular, methods for determining a potency and/or diffusion of a neurotoxin based on a nuclear index and/or an amount of muscle atrophy are disclosed. The methods may be used to distinguish two different Clostridial neurotoxins. In certain embodiments, the neurotoxins are obtained from Clostridium botulinum.
Public/Granted literature
- US20050019338A1 Nuclei density and nuclei area methods for determining effects of a botulinum toxin on muscles Public/Granted day:2005-01-27
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