Invention Grant
- Patent Title: Computational method and apparatus for predicting polypeptide aggregation or solubility
- Patent Title (中): 用于预测多肽聚集或溶解度的计算方法和装置
-
Application No.: US11184548Application Date: 2005-07-19
-
Publication No.: US07379824B2Publication Date: 2008-05-27
- Inventor: Christopher Dobson , Fabrizio Chiti , Jesus Zurdo
- Applicant: Christopher Dobson , Fabrizio Chiti , Jesus Zurdo
- Applicant Address: GB Cambridge
- Assignee: Cambridge University Technical Services Ltd.
- Current Assignee: Cambridge University Technical Services Ltd.
- Current Assignee Address: GB Cambridge
- Agency: Schwegman, Lundberg & Woessner P.A.
- Priority: GB0301235.8 20030120
- Main IPC: G06F17/11
- IPC: G06F17/11 ; G06F17/50 ; G06F19/00
Abstract:
A prediction method for predicting the effect of an amino acid modification on the rate of aggregation (solubility) of a reference polypeptide comprising: calculating the difference in hydrophobicity (ΔHydr) between the reference polypeptide and a modified polypeptide, calculating the difference in β-sheet propensity (ΔΔGcoil-α+ΔΔGβ-coil) between the reference polypeptide and modified polypeptide, calculating the difference in charge (Δ Charge) between the reference polypeptide and modified polypeptide, and calculating: [x*ΔHydr]+[y*(ΔΔGcoil-α+ΔΔGβ-coil)]−[z*Δ Charge], wherein x, y and z are scaling factors.
Public/Granted literature
- US20060025977A1 Computational method and apparatus for predicting polypeptide aggregation or solubility Public/Granted day:2006-02-02
Information query
