Invention Grant
- Patent Title: Arylpiperaszine derivatives, to the process for the production thereof and to the use thereof as therapeutic agents
- Patent Title (中): 芳基哌嗪衍生物，其生产方法及其作为治疗剂的用途
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Application No.: US11252870Application Date: 2005-10-19
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Publication No.: US07432269B2Publication Date: 2008-10-07
- Inventor: Marc Capet , Denis Danvy , Nicolas Levoin , Marcel Morvan , Isabelle Berrebi-Bertrand , Thierry Calmels , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte
- Applicant: Marc Capet , Denis Danvy , Nicolas Levoin , Marcel Morvan , Isabelle Berrebi-Bertrand , Thierry Calmels , Philippe Robert , Jean-Charles Schwartz , Jeanne-Marie Lecomte
- Applicant Address: FR Paris
- Assignee: Bioprojet
- Current Assignee: Bioprojet
- Current Assignee Address: FR Paris
- Agency: Stites & Harbison PLLC
- Agent B. Aaron Schulman
- Priority: FR0411303 20041022
- Main IPC: A61K31/497
- IPC: A61K31/497 ; C07D401/00 ; C07D413/00 ; C07D417/00
Abstract:
The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent having the property of being selective ligands for the dopamine D3 receptor. These selective D3 ligands are useful as medicines in neuropsychiatry, in particular in the treatment of psychotic or depressive states, or in the treatment of motor disorders, such as dyskinesia or essential tremor. They are furthermore useful in the treatment of dependency on nicotine, cocaine, alcohol, opioids and for facilitating withdrawal in drug-dependent individuals.
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