An LCD panel with mixed substrate materials and a method of making the LCD panel are presented. The LCD panel is made of a first substrate, a second substrate disposed substantially parallel to the first substrate, and a liquid crystal layer disposed between the first substrate and the second substrate. The first substrate includes a glass substrate, a TFT formed on the glass substrate, and a color filter formed on the TFT. The second substrate includes a plastic substrate and a common electrode formed on the plastic substrate. Forming the color filter on the TFT eliminates the need to form black matrices on the second substrate, preventing misalignment of the two substrates due to different heat sensitivities. Since there is no concern of substrate misalignment caused by heat, laser beam can be used to cut the substrates during the manufacture of the LCD panel.