A cable protection and guide device is disclosed in which connection strength of the side plate portions is improved. The strength of connecting portions is improved and large scale assembly of the device is possible. Side plate portions (110) each have a link module (120) with integrally molded side plates (122) of a predetermined number interconnected by coupling portions (124). Each coupling portion includes flexible coupling arms (126) extended from the coupling portions (124). Stopper links (130) each being engaged between the adjacent side plates from a cable accommodating space side and are assembled to the coupling portion by a snap-fit mechanism. The link module has a male connecting plate (127) and a female connecting plate (128), which are respectively connected to link modules, which are reside at respective ends of the male connecting plate and the female connecting plate. The male connecting plate and the female connecting plate are each formed in the same outer shape as that of the side plate when connected to a female connecting plate and a male connecting plate of the adjacent link module.