Conditioned air discharged from a vehicle heating, ventilation and air conditioning (HVAC) unit is further conditioned by a thermoelectric (TE) air conditioning unit and then directed to air passages in a vehicle seat. Activation of the TE air conditioning unit is based on climate control parameters utilized by the HVAC unit, including a set temperature, radiant heating effects, and cabin air temperature. The climate control parameters are utilized to establish a target seat temperature that optimizes occupant comfort and the transient response of the seat cooling effect.