According to some embodiments of the present invention, a multi-protocol non-volatile memory (“NVM”) card may include a NVM array, at least two protocol units, and a controller adapted to provide an external application access to the NVM array with the use of one of the protocol units. The controller or control logic may select which protocol unit to use based on a signal or other indicator of the protocol used by the external application. According to some embodiments of the present invention, a method of operating a multi-protocol memory card may include switching between a first and a second protocol or mode of the card based on a signal from an application attempting to access to the NVM card.