Devices and methods for ligating and coagulating tissue are provided. In one embodiment, a device is provided having an end effector that is adapted to access tissue to be treated at a surgical site and has the capability to both ligate and coagulate the targeted tissue. The end effector can include at least one ligation band that is removably disposed in a delivery configuration on a portion of the end effector and is adapted to be configured in a tissue-engaging configuration upon release from the end effector. The end effector can also include a pair of spaced electrodes disposed adjacent to each other on a tissue contacting portion of the end effector.