Invention Grant
US07642051B2 Screening methods for the identification of inhibitors of human immunodeficiency virus (HIV) viral protein R (Vpr) binding to the adenine nucleotide translocator (ANT)
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鉴定人类免疫缺陷病毒（HIV）病毒蛋白R（Vpr）与腺嘌呤核苷酸转运蛋白（ANT）结合的抑制剂的筛选方法
- Patent Title: Screening methods for the identification of inhibitors of human immunodeficiency virus (HIV) viral protein R (Vpr) binding to the adenine nucleotide translocator (ANT)
- Patent Title (中): 鉴定人类免疫缺陷病毒（HIV）病毒蛋白R（Vpr）与腺嘌呤核苷酸转运蛋白（ANT）结合的抑制剂的筛选方法
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Application No.: US11176370Application Date: 2005-07-08
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Publication No.: US07642051B2Publication Date: 2010-01-05
- Inventor: Etienne Daniel Francois Jacotot , Guido Kroemer , Bernard Pierre Roques , Lena Edelman , Johan Hoebeke , Catherine Brenner-Jean , Anne-Sophie Belzacq
- Applicant: Etienne Daniel Francois Jacotot , Guido Kroemer , Bernard Pierre Roques , Lena Edelman , Johan Hoebeke , Catherine Brenner-Jean , Anne-Sophie Belzacq
- Applicant Address: FR Paris FR Paris FR Paris FR Compiegne
- Assignee: Institut Pasteur,Institut National de la Sante et de la Recherche Medicale,Centre National de la Recherche Scientifique,Universite de Technologie de Compiegne
- Current Assignee: Institut Pasteur,Institut National de la Sante et de la Recherche Medicale,Centre National de la Recherche Scientifique,Universite de Technologie de Compiegne
- Current Assignee Address: FR Paris FR Paris FR Paris FR Compiegne
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- Main IPC: C12Q1/70
- IPC: C12Q1/70 ; G01N33/53 ; A61K39/21
Abstract:
The invention is directed to the induction of mitochondrial membrane permeabilization via the physical and functional interaction of the HIV-1 Vpr protein with the mitochondrial inner membrane protein ANT (adenine nucleotide translocator, also called adenine nucleotide translocase or ADP/ATP carrier). Reagents and methods for inducing and/or inhibiting the binding of Vpr to ANT, mitochondrial membrane permeabilization, and apoptosis are provided.
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