Invention Grant
US07642249B2 Dihydrogen phosphate salt of a prostaglandin D2 receptor antagonist
失效
前列腺素D2受体拮抗剂磷酸二氢盐
- Patent Title: Dihydrogen phosphate salt of a prostaglandin D2 receptor antagonist
- Patent Title (中): 前列腺素D2受体拮抗剂磷酸二氢盐
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Application No.: US12101282Application Date: 2008-04-11
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Publication No.: US07642249B2Publication Date: 2010-01-05
- Inventor: Beverly Langevin , Edward Orton , Daniel Sherer
- Applicant: Beverly Langevin , Edward Orton , Daniel Sherer
- Applicant Address: US NJ Bridgewater
- Assignee: Aventis Pharmaceuticals Inc.
- Current Assignee: Aventis Pharmaceuticals Inc.
- Current Assignee Address: US NJ Bridgewater
- Agent Ronald G. Ort; Jiang Lin
- Main IPC: C07D239/46
- IPC: C07D239/46 ; A61K31/505

Abstract:
The present invention is directed to dihydrogen phosphate salt 2-(3-{6-[2-(2,4-dichloro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenyl)-2-methyl-propionic acid of Formula (III), a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of Formula (III), and a pharmaceutically acceptable carrier; and a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like, by administering to said patient a pharmaceutically effective amount of the compound of Formula (III).
Public/Granted literature
- US20080194600A1 DIHYDROGEN PHOSPHATE SALT OF A PROSTAGLANDIN D2 RECEPTOR ANTAGONIST Public/Granted day:2008-08-14
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