Invention Grant
- Patent Title: Arylipiperdinopropanol and arylipiperazinopropanol derivatives and pharmaceuticals containing the same
- Patent Title (中): 芳基哌啶丙醇和芳基哌嗪丙醇衍生物和含有它们的药物
-
Application No.: US11002793Application Date: 2004-12-03
-
Publication No.: US07642262B2Publication Date: 2010-01-05
- Inventor: Hirokazu Annoura , Kyoko Nakanishi , Shigeki Tamura
- Applicant: Hirokazu Annoura , Kyoko Nakanishi , Shigeki Tamura
- Applicant Address: JP Minato-ku, Tokyo
- Assignee: Asubio Pharma Co., Ltd.
- Current Assignee: Asubio Pharma Co., Ltd.
- Current Assignee Address: JP Minato-ku, Tokyo
- Agency: Drinker Biddle & Reath LLP
- Priority: JP9-301154 19971031
- Main IPC: A61K31/495
- IPC: A61K31/495 ; C07D295/135

Abstract:
A compound having the formula (I) or its salt, hydrate, hydrate salt or solvate: wherein R1 to R4 independently represent H, halogen, OH, alkoxy, optionally substituted alkyl, aryl, or aralkyl group, R5 represents H, optionally substituted alkyl, aryl, or aralkyl group, E1 represents O, S, or —NR6, where R6 represents H, an optionally substituted alkyl, aryl, or aralkyl group, E2 represents O, S, or —NR7, where R7 represents H, an optionally substituted alkyl, aryl, or aralkyl group, A represents CH, C(OH), or N, X represents H, halogen, alkoxy, or an optionally substituted alkyl group, and Q represents an optionally substituted phenyl group, phenoxy, phenylmethyl, or cycloalkyloxy group, where when E1 represents O or S, E2 does not represent O or S, which has an action of suppressing the cytotoxic Ca2+ overload and lipid peroxidation and effective for pharmaceutical preparation for the alleviation and treatment of symptoms due to ischemic diseases, etc.
Public/Granted literature
- US20050101610A1 Arylipiperdinopropanol and arylipiperazinopropanol derivatives and pharmaceuticals containing the same Public/Granted day:2005-05-12
Information query