Invention Grant
- Patent Title: Mitochrondrial permeability transition pore affinity labels and modulators
- Patent Title (中): 线粒体通透性转移孔亲和标记和调节剂
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Application No.: US11487119Application Date: 2006-07-14
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Publication No.: US07642283B2Publication Date: 2010-01-05
- Inventor: Andrea Cesura , Emmanuel Pinard
- Applicant: Andrea Cesura , Emmanuel Pinard
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- Priority: EP03008040 20030414
- Main IPC: A61K31/352
- IPC: A61K31/352 ; C07D311/22 ; C12Q1/00
Abstract:
Methods of utilizing compounds of general formulas I and II as modulators and affinity labels of the MPTP complex are elucidated. Furthermore, methods for modulating the activity of the MPTP complex, methods for determining the presence of a component of the MPTP complex, and methods for identifying an active agent that modulates the activity of the MPTP complex, specifically methods for identifying an active agent that modulates the activity of the MPTP complex by interacting with the VDAC1 component are identified. Moreover, novel compounds of general formulas I and II are disclosed.
Public/Granted literature
- US20060252822A1 Mitochrondrial permeability transition pore affinity labels and modulators Public/Granted day:2006-11-09
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