Invention Grant
- Patent Title: PEG-functional nucleic acid conjugate
- Patent Title (中): PEG-功能核酸缀合物
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Application No.: US11578560Application Date: 2005-04-14
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Publication No.: US07642343B2Publication Date: 2010-01-05
- Inventor: Yukio Nagasaki , Kazunori Kataoka , Shigeki Sasaki , Fumi Nagatsugi , Motoi Oishi
- Applicant: Yukio Nagasaki , Kazunori Kataoka , Shigeki Sasaki , Fumi Nagatsugi , Motoi Oishi
- Applicant Address: JP Saitama
- Assignee: Japan Science and Technology Agency
- Current Assignee: Japan Science and Technology Agency
- Current Assignee Address: JP Saitama
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2004-122124 20040416
- International Application: PCT/JP2005/007568 WO 20050414
- International Announcement: WO2005/100447 WO 20051027
- Main IPC: C07H21/00
- IPC: C07H21/00 ; C07H21/02 ; C12Q1/68
Abstract:
The invention provides a conjugate of functional oligonucleotide with poly(ethylene oxide), polyion complex of the conjugate with cationic polymer, and micelle thereof. The micelle improves stability of the oligonucleotide in animal cells and its specific bindability to target gene.
Public/Granted literature
- US20080097087A1 Peg-functional nucleic acid conjugate Public/Granted day:2008-04-24
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